Anti-insulin antibody test

定义

The anti-insulin antibody test checks to see if your body has produced 抗体 对胰岛素.

Antibodies are proteins the body produces to protect itself when it detects anything foreign, such as a virus or transplanted organ.

选择的名字

Insulin 抗体 - serum; Insulin Ab test; Insulin resistance - insulin 抗体; Diabetes - insulin 抗体

How the Test is Performed

A 血液样本 是必要的.

How to Prepare for the Test

No special preparation 是必要的.

考试的感觉如何

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. 这很快就会消失.

Why the Test is Performed

This test may be performed if:

• You have or are at risk for 1型糖尿病
• You appear to have an allergic response to insulin
• Insulin no longer seems to control your diabetes
• You are taking insulin to control your diabetes and your blood sugar level varies a lot, with both high and low numbers that can't be explained by the food you are eating relative to the timing of your insulin injections

正常的结果

Normally, there are no 抗体 对胰岛素 in your blood. Antibodies can be found in the blood of many people who are taking insulin to control diabetes.

Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your health care provider about the meaning of your specific test results.

What Abnormal Results Mean

The presence of IgG and IgM 抗体 对胰岛素 can be part of the testing that diagnoses you with 1型糖尿病.

If you develop anti-insulin 抗体, insulin may not work as well, or it may not work at all. As a result, your blood sugar can be very high. Or the 抗体 can also put you at risk for low blood sugar.

Your provider may suggest a different form of insulin to which your body may be less likely to form 抗体.

If the test shows a high level of IgE antibody 对胰岛素, your body has developed an allergic response to the insulin.

• This could put you at risk for skin reactions where you inject insulin. You can also develop more severe reactions that affect your blood pressure or breathing.
• Medicines, such as antihistamines or low-dose injectable steroids, may help. Or you may need a treatment process called desensitization or a treatment to remove the 抗体 from your blood.

风险

There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Obtaining a 血液样本 from some people may be more difficult than from others.

Other risks of having blood drawn are slight, but may include:

• 大出血
• Fainting or feeling lightheaded
• Multiple punctures to locate veins
• 血肿 (blood building up under the skin)
• Infection (a slight risk any time the skin is broken)

参考文献

Atkinson MA, Mcgill DE, Dassau E, Laffel L. Type 1 diabetes mellitus. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14日艾德. Philadelphia, PA: Elsevier; 2020:chap 36.

Kahn CR, Ferris HA, O'Neill BT. Pathophysiology of type 2 diabetes mellitus. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14日艾德. Philadelphia, PA: Elsevier; 2020:chap 34.